Human immunodeficiency virus reverse transcriptase and protease sequence database.

Soo-Yon Rhee; Matthew J Gonzales; Rami Kantor; Bradley J Betts; Jaideep Ravela; Robert W Shafer

doi:10.1093/nar/gkg100

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Human immunodeficiency virus reverse transcriptase and protease sequence database.

Soo-Yon Rhee·Matthew J Gonzales·Rami Kantor·Bradley J Betts·Jaideep Ravela·Robert W Shafer

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Abstract

The HIV reverse transcriptase and protease sequence database is an on-line relational database that catalogues evolutionary and drug-related sequence variation in the human immunodeficiency virus (HIV) reverse transcriptase (RT) and protease enzymes, the molecular targets of antiretroviral therapy (http://hivdb.stanford.edu). The database contains a compilation of nearly all published HIV RT and protease sequences, including submissions to GenBank, sequences published in journal articles and sequences of HIV isolates from persons participating in clinical trials. Sequences are linked to data about the source of the sequence, the antiretroviral drug treatment history of the person from whom the sequence was obtained and the results of in vitro drug susceptibility testing. Sequence data on two new molecular targets of HIV drug therapy--gp41 (cell fusion) and integrase--will be added to the database in 2003.

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Amino Acid Sequence Anti-HIV Agents Databases, Protein Drug Design Drug Resistance, Viral Genetic Variation HIV Infections HIV Protease HIV Protease Inhibitors HIV Reverse Transcriptase HIV-1 Humans Mutation Phenotype Sequence Alignment Sequence Analysis, Protein Journal Article

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Soo-Yon Rhee, Matthew J Gonzales, Rami Kantor, Bradley J Betts, Jaideep Ravela, Robert W Shafer. 2003-01-01. Human immunodeficiency virus reverse transcriptase and protease sequence database.. https://doi.org/10.1093/nar%2Fgkg100

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