Cortical columns: a multi-parameter examination.

Ralph D Freeman

doi:10.1093/cercor/13.1.70

Home/Archive/PubMed

PubMed · 12466217

Cortical columns: a multi-parameter examination.

Ralph D Freeman

View original source ↗Export metadata ↓

Abstract

Columnar structure in the cerebral cortex has been demonstrated in numerous studies. However, in the visual system, it is not clear from imaging, basic physiological and anatomical approaches how multiple stimulus parameters are related within columns. We have analyzed recordings from pairs of neurons in the striate cortex of the cat using various spatial and temporal parameters. We find that most parameters are clustered within inferred columns with the exception of spatial phase. Diversity of phase could be useful for serial processing in central visual pathways.

Explore related subjects

Action Potentials Animals Cats Cluster Analysis Evoked Potentials, Visual Interneurons Nerve Net Photic Stimulation Sensitivity and Specificity Statistics as Topic Visual Cortex Visual Perception Journal Article Research Support, U.S. Gov't, P.H.S.Review

Keep this discovery

Explore connections, maps & timelines

BibTeX RIS

Ralph D Freeman. 2003. Cortical columns: a multi-parameter examination.. https://doi.org/10.1093/cercor%2F13.1.70

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed2003

Serial hearing organs in the atympanate grasshopper Bullacris membracioides (Orthoptera, Pneumoridae).

In different insect taxa, ears can be found on virtually any part of the body. Comparative anatomy and similarities in the embryological development of ears in divergent taxa suggest that they have evolved multiple times from ubiquitous stretch or vibration receptors, but the homology of these structures has not yet been rigorously tested. Here we provide detailed analysis of a novel set of hearing organs in a relatively "primitive" atympanate bladder grasshopper (Bullacris membracioides) that is capable of signaling acoustically over 2 km. We use morphological, physiological, and behavioral experiments to demonstrate that this species has six pairs of serially repeated abdominal ears derived from proprioceptive pleural chordotonal organs (plCOs). We demonstrate continuity in auditory function from the five posterior pairs, which are simple forms comprising 11 sensilla and resembling plCOs in other grasshoppers, to the more complex anterior pair, which contains 2000 sensilla and is homologous to the single pair of tympanate ears found in "modern" grasshoppers. All 12 ears are morphologically differentiated, responsive to airborne sound at frequencies and intensities that are biologically significant (tuned to 1.5 and 4 kHz; 60-98 dB SPL), and capable of mediating behavioral responses of prospective mates. These data provide evidence for the transition in function and selective advantage that must occur during evolutionary development of relatively complex organs from simpler precursors. Our results suggest that ancestral insects with simple atympanate pleural receptors may have had hearing ranges that equal or exceed those of contemporary insects with complex tympanal ears. Moreover, auditory capability may be more prevalent among modern insect taxa than the presence of overt tympana indicates.

Action Potentials↗

PubMed2003

Thermal properties of acid-induced depolarization in cultured rat small primary afferent neurons.

Tissue ischemia and inflammation result in localized acidosis, and acidic pH can trigger a sensation of pain. Pain is known to be often modified by the tissue temperature. The purpose of this study is to clarify the thermal behavior of nociceptors in response to acidification using intracellular recordings from cultured rat primary afferent neurons. Extracellular acidification induced depolarization of two types, transient and sustained responses. The former (to pH 6.3 and 5.2) was augmented at lower temperature (26, 16 degrees C) and amiloride blocked the response to pH 6.3 at 26 degrees C. On the other hand, the sustained depolarization, which often followed the transient one, in response to pH 6.3 was greater at 36 degrees C and significantly blocked by capsazepine at 36 degrees C, but not at 26 degrees C. The sustained response to pH 5.2 was blocked even at 26 degrees C. These results suggest that the low pH evoked depolarization is temperature-dependent, and the contribution of transient receptor potential V1 (vanilloid receptor 1) to proton-induced response is greater in the physiological body temperature range, while that of the acid-sensing-ion-channel family is greater at room temperature or lower.

Action Potentials↗

PubMed2003

Comparison of reorganization of the somatosensory system in rats that sustained forelimb removal as neonates and as adults.

Studies of sensory pathways in several species indicate that the extent and form of reorganization resulting from deafferentation early in life vs. adulthood are not the same. The reasons for such differences are not well understood. To gain further insight into age-dependent mechanisms of reorganization, this study compared the consequences of neonatal vs. adult forelimb amputation in rats at multiple levels of the sensory pathway, including primary somatosensory cortex, brainstem, and dorsal root ganglia. At the cortical level, the average area of the functional forelimb-stump representation from rats amputated as adults was significantly smaller (P < 0.05) than that of neonatally amputated rats (4.3 +/- 1.3 mm(2) vs. 6.6 +/- 1.5 mm(2), respectively). At the brainstem level, neonatally amputated rat cuneate neurons possessed the following responsivities: 20% stump responsive, 40% responsive to both stump and hindlimb, 30% responsive to another body region, and 10% unresponsive. In contrast, cuneate neurons of adult amputated rats were 70% stump responsive, 2% responsive to both stump and hindlimb, and 30% unresponsive. A significantly (P < 0.001) greater percentage of the C(6)-C(8) dorsal root ganglia neurons of adult amputated rats were unresponsive to peripheral stimulation vs. neurons from neonatally amputated rats (48% vs. 16%, respectively). These results indicate that the reorganization that occurs in response to forelimb amputation at birth vs. adulthood is distinctly different at each of these levels of the dorsal column-medial lemniscal pathway. Possible mechanisms to account for these differences are considered.

Action Potentials↗