PubMed · 12357969
The source did not provide an abstract. Follow the original record for more information.
Explore connections, maps & timelines
Ramona Volkert. 2002-08-23. [Knowledge put into action].. https://pubmed.ncbi.nlm.nih.gov/12357969/
Cite the original work for its findings. Save a collection to share your selection of sources.
KEEP EXPLORING
A rebound in the plasma and seminal viral load was detected in 12 patients after the interruption of effective highly active antiretroviral therapy. The viral rebound was generally higher in plasma, although the highest level observed during interruption was higher in semen in two patients. The reintroduction of therapy was followed by an overall decrease in HIV-RNA in plasma and semen. One to 2 months after restarting treatment, four out of seven patients showed undetectable HIV-RNA in semen.
Self-reported adherence and plasma protease inhibitor concentration (PPIC) were assessed in 642 HIV-infected patients at month 4 of a single protease inhibitor-containing regimen. PPIC was below the limit of quantification (LOQ) in 32% of non-adherent patients and in 8% of adherent patients. The relationship between non-adherence and a detectable HIV viral load was enhanced when adherent patients with PPIC below LOQ were considered to be non-adherent. PPIC combined with self-report may more reliably detect non-adherence.
Explore the source record for details and available documents.