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PubMed · 12175809

Checking cell size in yeast.

Ivan Rupes
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Abstract

To remain viable, cells have to coordinate cell growth with cell division. In yeast, this occurs at two control points: the boundaries between G1 and S phases, also known as Start, and between G2 and M phases. Theoretically, coordination can be achieved by independent regulation of growth and division, or by participation of surveillance mechanisms in which cell size feeds back into cell-cycle control. This article discusses recent advances in the identification of sizing mechanisms in budding and in fission yeast, and how these mechanisms integrate with environmental stimuli. A comparison of the G1-S and G2-M size-control modules in the two species reveals a degree of conservation higher than previously thought. This reinforces the notion that internal sizing could be a conserved feature of cell-cycle control throughout eukaryotes.

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Cell CycleCell Cycle ProteinsCell DivisionCell SizeSaccharomyces cerevisiaeSpecies SpecificityComparative StudyJournal ArticleReview

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Ivan Rupes. 2002. Checking cell size in yeast.. https://doi.org/10.1016/s0168-9525(02)02745-2

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