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PubMed · 1212993

[Deiodination in the kidney and thyroid function)].

C Voss·K Hartmann·N Hartmann·L Ratzmann
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Abstract

In homogenate supernatants of kidneys of male rats the extent of deiodination of L-diiodotyrosine (L-DJT) and L-thyroxine (L-T4) was investigated in dependence on the thyroid function (hypo- and hyperthyroidized) and also in dependence on age. In rats hypothyroidized by loading with Methylthiouracil (MTU) or Methimazol (MMI) the deiodination for L-DJT and L-T4 was significantly reduced, in rats loaded with 40 mug T4 sc. for 10 days, the deiodination was significantly enhanced compared with untreated control animals. With advancing age (6 weeks, 3 or 12 month) the deiodination activity is highly significantly reduced. The results underline relations between thyroid gland function and deiodination activity in kidney.

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Age FactorsAnimalsDiiodotyrosineHyperthyroidismHypothyroidismIodineKidneyMaleMethimazoleMethylthiouracilMonoiodotyrosineRatsThyroid DiseasesThyroid HormonesThyroxineTriiodothyronineEnglish AbstractJournal Article

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C Voss, K Hartmann, N Hartmann, L Ratzmann. 1975. [Deiodination in the kidney and thyroid function)].. https://pubmed.ncbi.nlm.nih.gov/1212993/

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