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PubMed · 12102345

Epimerization study on [18f]FDG produced by an alkaline hydrolysis on solid support under stringent conditions.

C Mosdzianowsk·C Lemaire·F Simoens·J Aerts·J L Morelle·A Luxen
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Abstract

Since 1998, routine [18F]FDG syntheses are being carried out by alkaline hydrolysis on a solid support, i.e. the labeled intermediate is trapped on a tC18 solid phase extraction cartridge, purified and finally hydrolyzed within the cartridge, at room temperature, using sodium hydroxide. The present study demonstrated that no epimerization of [18F]FDG to [18F]FDM occurs even when 12 N NaOH is used and when the hydrolysis time is extended up to 1 h. The alkaline hydrolysis on solid support appears to be a simple method leading to [18F]FDG with high purity.

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Fluorodeoxyglucose F18Hydrogen-Ion ConcentrationHydrolysisIsomerismRadiopharmaceuticalsSodium HydroxideJournal Article

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C Mosdzianowsk, C Lemaire, F Simoens, J Aerts, J L Morelle, A Luxen. 2002. Epimerization study on [18f]FDG produced by an alkaline hydrolysis on solid support under stringent conditions.. https://doi.org/10.1016/s0969-8043(01)00145-2

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Fluorodeoxyglucose F18↗