PubMed · 12055555
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A Dupuy, J C Guillaume. 2002. [Accurate and precise].. https://pubmed.ncbi.nlm.nih.gov/12055555/
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We evaluated the performance of commonly used methods for estimating the reliability of binomial health care quality measures using simulated datasets spanning a range of performance score means and variances, numbers of entities, and patient sample sizes. For each simulation, reliability was estimated for all selected methods and compared with the known true reliability derived from the simulation parameters, with methods assessed on their accuracy and precision. Logistic regression with reliability estimated on the outcome scale demonstrated the highest accuracy and precision among all methods evaluated. The widely used Adams beta-binomial method performed poorly, although a modification recommended by Nieser and Harris substantially improved its performance. These approaches are applicable only to binomial measures. Among methods that can be applied to both binomial and continuous measures, permutation resampling of the Spearman rank correlation coefficient was the most accurate and precise, outperforming other commonly used approaches. Overall, for binomial quality measures, logistic regression on the outcome scale is the preferred method for reliability estimation, followed closely by the modified beta-binomial approach, while for non-binomial measures, permutation-based Spearman rank correlation appears to be the most suitable method.
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BACKGROUND: The formulation of sulphamethoxazole (S) and trimethoprin (T) (CO-TRIMOXAZOLE) in a combination mixture is very good pharmacologically since it enhances the efficacy of the individual drugs. However in this combination, difficulties in analysis on ordinary UV spectrophotometry are introduced because the two components give overlapping spectral bands on zero-order. The United States Pharmacopoea (USP)-recommended HPLC analytical method is quite expensive. OBJECTIVE: The objective of the present work was to assess whether derivative spectrophotometry could be used to circumvent the overlapping spectral bands of the components and hence use it for routine analysis of the drug. STUDY DESIGN: Experimental. METHODS: The aqueous solution of the individual drugs and their binary mixtures were scanned on zero order and on first derivative at the wave length between 200- 300 nm and at the pH of 4.5. RESULTS: The zero-order spectra of the compounds were completely overlapping. However the first-derivative scan offered better separation and hence T was determined from the absorbance at 237.6 nm with negligible contribution from S (since at this point it was reading zero). Likewise S was determined at a wavelength of 259 nm when T was reading zero. The linear calibration graphs were obtained for 4-25 microg x ml(-1) of S and for 4-20 microg x ml(-1) of T. CONCLUSION: The method is rapid, simple and can be applied successfully to assay a mixture of the two drugs in pharmaceutical preparations.