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PubMed · 11929600

Morphogen gradient formation and vesicular trafficking.

Eugeni V Entchev·Marcos A González-Gaitán
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Abstract

Morphogens are secreted signaling molecules which form spatial concentration gradients while moving away from a restricted source of production. A simple model of gradient formation postulates that the morphogens dilute as they diffuse between cells. In this review we discuss recent data supporting the idea that movement of the morphogen could also occur via vesicular trafficking through the cells. We explore the implications of these results for the control of gradient formation and the determination of the gradient slope which ultimately encodes the coordinates of positional information.

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ActivinsAnimalsBiological TransportDrosophilaDrosophila ProteinsDynaminsEndosomesGTP PhosphohydrolasesHedgehog ProteinsLysosomesModels, BiologicalProto-Oncogene ProteinsSignal TransductionTransforming Growth Factor betaWnt1 ProteinXenopusrab GTP-Binding Proteinsrab5 GTP-Binding Proteinsrab7 GTP-Binding ProteinsJournal ArticleResearch Support, Non-U.S. Gov'tReview

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Eugeni V Entchev, Marcos A González-Gaitán. 2002. Morphogen gradient formation and vesicular trafficking.. https://doi.org/10.1034/j.1600-0854.2002.030203.x

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