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PubMed · 11916106

How does sibutramine work?

M E Lean
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Abstract

Sibutramine offers three types of benefit in weight management: by enhancing weight loss, by improving weight maintenance and by reducing the comorbidities of obesity. The clinical effects of sibutramine are explained through its known mode of action as a serotonin (5-HT) and noradrenaline reuptake inhibitor (SNRI). This dual mechanism of action results in two synergistic physiological effects--a reduction in energy intake and an increase in energy expenditure, which combine to promote and maintain weight loss.

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Appetite DepressantsCyclobutanesDose-Response Relationship, DrugEnergy IntakeEnergy MetabolismHumansObesitySelective Serotonin Reuptake InhibitorsJournal ArticleReview

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BibTeXRIS

M E Lean. 2001. How does sibutramine work?. https://doi.org/10.1038/sj.ijo.0801931

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