A versatile structural domain analysis server using profile weight matrices.

Steffen Schmidt; Peer Bork; Thomas Dandekar

doi:10.1021/ci010374r

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A versatile structural domain analysis server using profile weight matrices.

Steffen Schmidt·Peer Bork·Thomas Dandekar

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Abstract

The WEB tool "AnDom" assigns to a given protein sequence all experimentally determined structural domains contained within it, including multidomain and large proteins. The server uses profile specific matrices from custom generated multiple sequence alignments of all known SCOP domains (SCOP version 1.50). Prediction time is short allowing numerous applications for structural genomics including investigation of complex eucaryotic protein families. The WWW server is at http://www.bork.embl-heidelberg.de/AnDom, and profiles can be downloaded at ftp.bork.embl-heidelberg.de/pub/users/ schmidt/AnDom.

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Amino Acid Sequence Databases, Protein Molecular Sequence Data Protein Conformation Proteins Sequence Homology, Amino Acid Journal Article Research Support, Non-U.S. Gov't

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Steffen Schmidt, Peer Bork, Thomas Dandekar. A versatile structural domain analysis server using profile weight matrices.. https://doi.org/10.1021/ci010374r

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