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PubMed · 11911661

Strategies for multiple sequence alignment.

Hugh B Nicholas·Alexander J Ropelewski·David W Deerfield
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Abstract

We present an overview of multiple sequence alignments to outline the practical consequences for the choices among different techniques and parameters. We begin with a discussion of the scoring methods for quantifying the quality of a multiple sequence alignment, followed by a discussion of the algorithms implemented within a variety of multiple sequence alignment programs. We also discuss additional alignment details such as gap penalty and distance metrics. The paper concludes with a discussion on how to improve alignment quality and the limitations of the techniques described in this paper

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AlgorithmsEvolution, MolecularModels, GeneticSequence AlignmentSoftwareJournal ArticleResearch Support, U.S. Gov't, P.H.S.Review

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Hugh B Nicholas, Alexander J Ropelewski, David W Deerfield. 2002. Strategies for multiple sequence alignment.. https://doi.org/10.2144/02323rv01

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