Peroxisome proliferator-activated receptor (PPAR) agonists decrease lipoprotein lipase secretion and glycated LDL uptake by human macrophages.

F G Gbaguidi; G Chinetti; D Milosavljevic; E Teissier; J Chapman; G Olivecrona; J C Fruchart; S Griglio; J Fruchart-Najib; B Staels

doi:10.1016/s0014-5793(02)02223-8

PubMed · 11852057

Peroxisome proliferator-activated receptor (PPAR) agonists decrease lipoprotein lipase secretion and glycated LDL uptake by human macrophages.

F G Gbaguidi·G Chinetti·D Milosavljevic·E Teissier·J Chapman·G Olivecrona·J C Fruchart·S Griglio·J Fruchart-Najib·B Staels

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Abstract

Lipoprotein lipase (LPL) acts independently of its function as triglyceride hydrolase by stimulating macrophage binding and uptake of native, oxidized and glycated LDL. Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors expressed in monocyte/macrophages, where they control cholesterol homeostasis. Here we study the role of PPARs in the regulation of LPL expression and activity in human monocytes and macrophages. Incubation of human monocytes or macrophages with PPARalpha or PPARgamma ligands increases LPL mRNA and intracellular protein levels. By contrast, PPAR activators decrease secreted LPL mass and enzyme activity in differentiated macrophages. These actions of PPAR activators are associated with a reduced uptake of glycated LDL and could influence atherosclerosis development associated with diabetes.

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Biological Transport Cell Differentiation Glycation End Products, Advanced Humans Lipoprotein Lipase Lipoproteins, LDL Macrophages Monocytes Receptors, Cytoplasmic and Nuclear Transcription Factors Glycated Proteins Journal Article Research Support, Non-U.S. Gov't

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F G Gbaguidi, G Chinetti, D Milosavljevic, E Teissier, J Chapman, G Olivecrona, J C Fruchart, S Griglio, J Fruchart-Najib, B Staels. 2002-02-13. Peroxisome proliferator-activated receptor (PPAR) agonists decrease lipoprotein lipase secretion and glycated LDL uptake by human macrophages.. https://doi.org/10.1016/s0014-5793(02)02223-8

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