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PubMed · 11834313

Decrease of the electroacupuncture-induced analgesic effects in nuclear factor-kappa B1 knockout mice.

Hi-Joon Park·Hyang-Sook Lee·Hye-Jung Lee·Yeong-Min Yoo·Hee Jae Lee·Soon Ae Kim·Kanghyun Leem·Ho-Chul Kim·Jung-Chul Seo·Ee-Hwa Kim·Sabina Lim·Joo-Ho Chung
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Abstract

To investigate the involvement of nuclear factor kappa B1 (NF-kappaB1; p50/p105) in electroacupuncture (EA)-induced analgesia, 2 and 100 Hz EA stimulations were applied at acupoint ST36 (Zusanli) in NF-kappaB1 knockout mice. EA was performed for 30 min and tail-flick latencies (TFLs) were evaluated every 15 min for 1 h. Wild-type mice displayed a 63.3% increase in TFLs compared to baseline after 2 Hz EA, whereas NF-kappaB1+/- mice exhibited a 41.8% increase and NF-kappaB1-/- mice showed only a 3.9% increase of TFLs. The TFLs of 100 Hz EA showed similar trends: a 72.6% increase of TFLs in wild-type, a 38.6% increase in NF-kappaB1+/- and a 9.3% increase in NF-kappaB1-/- mice. The present findings suggest that NF-kappaB1 may play a crucial role in both low and high frequency EA-induced analgesic effects.

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AnalgesiaAnimalsElectroacupunctureFemaleMaleMiceMice, KnockoutNF-kappa BPainPain MeasurementProtein IsoformsReaction TimeTailJournal ArticleResearch Support, Non-U.S. Gov't

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Hi-Joon Park, Hyang-Sook Lee, Hye-Jung Lee, Yeong-Min Yoo, Hee Jae Lee, Soon Ae Kim, Kanghyun Leem, Ho-Chul Kim, Jung-Chul Seo, Ee-Hwa Kim, Sabina Lim, Joo-Ho Chung. 2002-02-22. Decrease of the electroacupuncture-induced analgesic effects in nuclear factor-kappa B1 knockout mice.. https://doi.org/10.1016/s0304-3940(01)02582-4

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