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PubMed · 11801174

Epigenetics as a first exit problem.

E Aurell·K Sneppen
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Abstract

We develop a framework to discuss the stability of epigenetic states as first exit problems in dynamical systems with noise. We consider in particular the stability of the lysogenic state of the lambda prophage. The formalism defines a quantitative measure of robustness of inherited states.

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Bacteriophage lambdaBinding SitesDNA, ViralDNA-Binding ProteinsEscherichia coliGene Expression Regulation, ViralLysogenyModels, GeneticRepressor ProteinsViral ProteinsViral Regulatory and Accessory ProteinsJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, Non-P.H.S.

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E Aurell, K Sneppen. 2002-01-08. Epigenetics as a first exit problem.. https://doi.org/10.1103/physrevlett.88.048101

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