Search PubMed⌕ Search
Home/Archive/PubMed

PubMed · 11790603

Recent developments in combinatorial organic synthesis.

A Ganesan
View original source ↗Export metadata ↓

Abstract

The level of sophistication of combinatorial synthesis continues to increase at a heady pace. Fairly complex target molecules are now being assembled combinatorially using a broad palette of organic reactions both in solution- and solid-phase. This review highlights academic and industrial examples of combinatorial synthesis published within the last year. Recent advances in small-molecule synthesis are outlined, ranging from simple acyclic scaffolds to complex natural products.

Explore related subjects

Biological FactorsCombinatorial Chemistry TechniquesHeterocyclic CompoundsHydrocarbons, AcyclicJournal ArticleReview

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

A Ganesan. 2002-01-01. Recent developments in combinatorial organic synthesis.. https://doi.org/10.1016/s1359-6446(01)02087-6

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed2007

C-type natriuretic peptide: a new endothelium-derived hyperpolarizing factor?

Vascular relaxation mediated by endothelium-derived hyperpolarizing factor (EDHF) is important for resistance artery function and is underpinned by hyperpolarization of the smooth muscle cells of the blood vessel wall. Debate surrounds the identity of EDHF and its mechanism of action, with the consensus being that there is no universal EDHF. Regional differences in vascular function reflect the complex mechanisms of EDHF. Two primary mechanistic pathways are implicated: (i) myoendothelial gap junctions mediating the spread of endothelial cell hyperpolarization or small signaling molecules (or both) to the smooth muscle; and (ii) diffusible mediators released from the endothelium, including K+ and epoxyeicosatrienoic acids. Here, we discuss the evidence for and against C-type natriuretic peptide (CNP), the latest candidate for a diffusible mediator.

Biological Factors↗