PubMed · 1178637
The source did not provide an abstract. Follow the original record for more information.
Explore connections, maps & timelines
[Atherosclerosis].. https://pubmed.ncbi.nlm.nih.gov/1178637/
Cite the original work for its findings. Save a collection to share your selection of sources.
KEEP EXPLORING
Transglutaminases (TGases) are enzymes that are widely used in many biological systems for generic tissue stabilization purposes. Mutations resulting in lost activity underlie several serious disorders. In addition, new evidence documents that they may also be aberrantly activated in tissues and cells and contribute to a variety of diseases, including neurodegenerative diseases such as Alzheimer's and Huntington's diseases. In these cases, the TGases appear to be a factor in the formation of inappropriate proteinaceous aggregates that may be cytotoxic. In other cases such as celiac disease, however, TGases are involved in the generation of autoantibodies. Further, in diseases such as progressive supranuclear palsy, Huntington's, Alzheimer's and Parkinson's diseases, the aberrant activation of TGases may be caused by oxidative stress and inflammation. This review will examine the role and activation of TGases in a variety of diseases.
Explore the source record for details and available documents.
Explore the source record for details and available documents.