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PubMed · 1171617

General models for segregation analysis.

R C Elston·K C Yelverton
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Abstract

Theoretical details are given of various oligogenic models for segregation analysis that are available as a general segregation analysis ("GENSEG") package, programmed in FORTRAN iv. The models allow for up to two autosomal loci and one X-linked locus, normally distributed or dichotomous phenotypes, variable age of onset, and various ascertainment functions (including one that allows the probability of becoming a proband to be dependent on the age of onset). Current programs are limited to the analysis of 2-generational data, using the joint likelihood of the sibship and parental phenotypes, unless it can be assumed that the pedigrees being analyzed are a random sample from the population; half-sibships and twins, however, are explicitly allowed.

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Age FactorsChromosome MappingChromosomesFemaleGene FrequencyGenetic Diseases, InbornHumansModels, BiologicalPedigreePhenotypePregnancySex ChromosomesSex Determination AnalysisTwinsJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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R C Elston, K C Yelverton. 1975. General models for segregation analysis.. https://pubmed.ncbi.nlm.nih.gov/1171617/

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