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PubMed · 11583026

Decrease in platelet serotonin level in uterine cervix cancer patients.

C Deb·C Lakshmi·C Ray·M R Ray
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Abstract

Platelet serotonin (5-HT) concentration was measured by HPLC with electrochemical detection in 46 women suffering from cancer of the uterine cervix and 16 matched controls. About 53% reduction (p < 0.05) was recorded in platelet 5-HT level in cancer patients against a control value of 1.29 +/- 0.16 (mean +/- S.E.) nmol per 10(9) platelets. Depletion of intraplatelet 5-HT was positively correlated with clinical stage of the disease although a modest rise (p > 0.05) in platelet 5-HT was observed in patients at stage I. Serotonin release from platelets following activation with thrombin was considerably increased in cancer patients (38.2% compared to 17.4% in controls). The results demonstrate progressive depletion of intraplatelet 5-HT in cervical cancer patients. In addition, their platelets release more 5-HT than the controls upon activation by thrombin.

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Biomarkers, TumorBlood PlateletsCase-Control StudiesChromatography, High Pressure LiquidFemaleHumansNeoplasm StagingSerotoninThrombinUterine Cervical NeoplasmsJournal Article

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C Deb, C Lakshmi, C Ray, M R Ray. 2001. Decrease in platelet serotonin level in uterine cervix cancer patients.. https://doi.org/10.1163/15685590152492954

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