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PubMed · 11525567

Technology evaluation: IMC-1C11, ImClone Systems.

S Hunt
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Abstract

ImClone is developing IMC-IC11, an anti-angiogenesis chimeric monoclonal antibody specific vascular endothelial growth factor receptor 2 (VEGFR-2, also known Flk-1 in mice), for the potential treatment of cancer [156625]; it in phase I trials for the treatment of colorectal carcinoma [379143]. The related antibody DC-101 provided proof-of-principle that an anti-VEGF receptor antibody could strongly inhibit tumor growth and even cause tumor regression with the glioblastoma tumor cell line, GBM18 [388236]. In May 1998, the company was granted US-05747651 by the USPTO, covering antibodies against the extracellular portion of the FLK-1/KDR receptor [284054].

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Angiogenesis InhibitorsAntibodies, MonoclonalColorectal NeoplasmsHumansReceptor Protein-Tyrosine KinasesReceptors, Growth FactorReceptors, Vascular Endothelial Growth FactorRecombinant Fusion ProteinsClinical TrialClinical Trial, Phase IJournal Article

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S Hunt. 2001. Technology evaluation: IMC-1C11, ImClone Systems.. https://pubmed.ncbi.nlm.nih.gov/11525567/

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