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PubMed · 11474959

Does aging adversely affect muscle mitochondrial function?

K R Short·K S Nair
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Abstract

Muscle oxidative function appears to decline with aging, and evidence suggests that this is related to reduced synthesis of mitochondrial and other muscle proteins. Causes for these events may include mtDNA damage or reduced mtDNA copy numbers, reduced oxidative enzyme activities and ATP production, and increased proton leak.

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Adenosine TriphosphateAdolescentAdultAgedAgingAnimalsCell RespirationDNA, MitochondrialExerciseHumansMiddle AgedMitochondria, MuscleMitochondrial ProteinsMuscle, SkeletalMutagenesisOxidative StressOxidoreductasesRNARNA, MitochondrialRatsJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.Review

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K R Short, K S Nair. 2001. Does aging adversely affect muscle mitochondrial function?. https://doi.org/10.1097/00003677-200107000-00006

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