PubMed · 11340519
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C López de Letona. 2001. [Ocular ossification].. https://pubmed.ncbi.nlm.nih.gov/11340519/
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Single-locus disorders in domesticated animals were among the first Mendelian traits to be documented after the rediscovery of Mendelism, and to be included in early linkage maps. The use of linkage maps and (increasingly) comparative genomics has been central to the identification of the causative gene for single-locus disorders of considerable practical importance. The 'score-card' in domestic animals is now more than 100 disorders for which the molecular lesion has been identified and hence for which a DNA test is available. Because of the limited lifespan of any such test, a cost-effective and hence popular means of protecting the intellectual property inherent in a DNA test is not to publish the discovery. While understandable, this practice creates a disconcerting precedent. For multifactorial disorders that are scored on an all-or-none basis or into many classes, the effectiveness of control schemes could be greatly enhanced by selection on estimated breeding values for liability. Genetic variation for resistance to pathogens and parasites is ubiquitous. Selection for resistance can therefore be successful. Because of the technical and welfare challenges inherent in the requirement to expose animals to pathogens or parasites in order to be able to select for resistance, there is a very active search for DNA markers for resistance. The first practical fruits of this research were seen in 2002, with the launch of a national scrapie control programme in the UK.
A report in The Veterinary Record of April 26 (pp 520-524) outlined the role of DEFRA's International Animal Health Division (IAHD) in international disease surveillance and management of legislative controls on trade in relation to diseases which could impact on Great Britain, summarising information gathered in 2002. This report reflects information received from January to May 31, 2003 (unless otherwise stated), and focuses on diseases in the EU and major trading partners
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