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PubMed · 11307497

[Cyclooxygenases].

P Eschwège·V de Ledinghen·T Camilli·S Kulkarni·G Dalbagni·S Droupy·A Jardin·G Benoît·B B Weksler
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Abstract

TWO ISOFORMS: There are two isoforms of cyclooxygenase (COX) with similar structure and metabolic activity. COX-1 is a constitutional enzyme. COX-2 is an inductible form. CYCLOOXYGENASE-1: COX-1 is present in most tissues, particularly in the kidney, the digestive tract mucosa, platelets, brain, liver and spleen. CYCLOOXYGENASE-2: COX-2 expression can be induced by an inflammatory process. Implicated in the development of certain cancers, COX-2 is expressed in numerous tumor cell lines and in most epithelial carcinomas. COX-2 favors tumor invasion and inhibits apoptosis. When it is absent, tumor growth is slower or stopped.

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ApoptosisCarcinomaCell Transformation, NeoplasticCyclooxygenase 1Cyclooxygenase 2HumansIsoenzymesMembrane ProteinsNeoplasm InvasivenessNeoplasms, Glandular and EpithelialProstaglandin-Endoperoxide SynthasesTumor Cells, CulturedEnglish AbstractJournal Article

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P Eschwège, V de Ledinghen, T Camilli, S Kulkarni, G Dalbagni, S Droupy, A Jardin, G Benoît, B B Weksler. 2001-03-17. [Cyclooxygenases].. https://pubmed.ncbi.nlm.nih.gov/11307497/

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