PubMed · 11293388
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A Kingston-Smith. 2001. Resource allocation.. https://doi.org/10.1016/s1360-1385(00)01842-2
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Cis-regulatory elements (CREs) are the genetic DNA fragments bound by transcription factors (TFs). CREs function as molecular switches that precisely modulate the dosage and spatiotemporal patterns of gene expression. The systematic identification of CREs not only facilitates the annotation of the functional non-coding genome but also provides essential insights into the architecture of gene regulatory networks and sheds light on an accurate selection of the target sites for genetic engineering of crops. In this review, we summarize the current high-throughput methodologies used for identifying CREs, illustrate the associations between CREs and agronomic traits in horticultural crops, and discuss how CREs can be exploited to facilitate crop breeding.
By the mid-1930s, according to Daniel Kevles, 'mainline eugenics had generally been recognized as a farrago of flawed science.' By then, most geneticists accepted that eugenic sterilization could not rid society of its undesirables. But paradoxically, eugenics still had supporters even among its scientist critics, whom Kevles called 'reform eugenicists'. My opinion is that there was no such sharp turning point in eugenics. Reliance on simple mendelian inheritance faded away, but eugenics continued much as before until after World War II. In this paper, I consider the history of the eugenics movement in terms of its concepts of the inheritance of 'feeble-mindedness' and psychosis as single-gene recessives, and sterilization as a means of control.
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