Search PubMed⌕ Search
Home/Archive/PubMed

PubMed · 11223641

Peroxynitrite-mediated mitochondrial dysfunction.

J Boczkowski·C L Lisdero·S Lanone·M C Carreras·M Aubier·J J Poderoso
View original source ↗Export metadata ↓

Abstract

Peroxynitrite anion (ONOO(-)) is a potent biological oxidant produced by the near diffusion-limited reaction of superoxide and nitric oxide. Peroxynitrite has been implicated in diverse forms of free radical-induced tissue injury. Experimental evidence showed that exogenous and endogenous peroxynitrite causes alterations of the structure and function of mitochondrial proteins, leading to mitochondrial dysfunction and cellular or organ injury. These data are discussed along with its physiopathological implications.

Explore related subjects

Energy MetabolismMitochondriaNitratesNitric OxideOxidantsOxidative StressOxygen ConsumptionJournal ArticleReview

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

J Boczkowski, C L Lisdero, S Lanone, M C Carreras, M Aubier, J J Poderoso. Peroxynitrite-mediated mitochondrial dysfunction.. https://doi.org/10.1159/000046876

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed2001

Motion detection in human vision: a unifying approach based on energy and features.

Most studies of human motion perception have been based on the implicit assumption that the brain has only one motion-detection system, or at least that only one is operational in any given instance. We show, in the context of direction perception in spatially filtered two-frame random-dot kinematograms, that two quite different mechanisms operate simultaneously in the detection of such patterns. One mechanism causes reversal of the perceived direction (reversed-phi motion) when the image contrast is reversed between frames, and is highly dependent on the spatial-frequency content of the image. These characteristics are both signatures of detection based on motion energy. The other mechanism does not produce reversed-phi motion and is unaffected by spatial filtering. This appears to involve the tracking of unsigned complex spatial features. The perceived direction of a filtered dot pattern typically reflects a mixture of the two types of behaviour in any given instance. Although both types of mechanism have previously been invoked to explain the perception of motion of different types of image, the simultaneous involvement of two mechanisms in the detection of the same simple rigid motion of a pattern suggests that motion perception in general results from a combination of mechanisms working simultaneously on different principles in the same circumstances.

Energy Metabolism↗
PubMed2001

Evolutionary relationship of Rickettsiae and mitochondria.

Phylogenetic data support an origin of mitochondria from the alpha-proteobacterial order Rickettsiales. This high-rank taxon comprises exceptionally obligate intracellular endosymbionts of eukaryotic cells, and includes family Rickettsiaceae and a group of microorganisms termed Rickettsia-like endosymbionts (RLEs). Most detailed phylogenetic analyses of small subunit rRNA and chaperonin 60 sequences consistently show the RLEs to have emerged before Rickettsiaceae and mitochondria sister clades. These data suggest that the origin of mitochondria and Rickettsiae has been preceded by the long-term mutualistic relationship of an intracellular bacterium with a pro-eukaryote, in which an invader has lost many dispensable genes, yet evolved carrier proteins to exchange respiration-derived ATP for host metabolites as envisaged in classic endosymbiont theory.

Energy Metabolism↗