Search PubMed⌕ Search
Home/Archive/PubMed

PubMed · 11187158

[Preventive thyroidectomy].

I Norheim
View original source ↗Export metadata ↓

Abstract

The source did not provide an abstract. Follow the original record for more information.

Explore related subjects

Carcinoma, MedullaryEthics, MedicalGenetic Predisposition to DiseaseHumansMultiple Endocrine Neoplasia Type 1Multiple Endocrine Neoplasia Type 2aThyroid NeoplasmsThyroidectomyEditorial

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

I Norheim. 2000-11-10. [Preventive thyroidectomy].. https://pubmed.ncbi.nlm.nih.gov/11187158/

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed2002

Medullary thyroid carcinomas in cell culture--models for future therapies.

We report the successful establishment of seven human medullary thyroid carcinomas (MTC) as continuous cell lines. Characteristic features--such as the presence of neuroendocrine granules--and the positive immunoreactivity to antibodies to CT, CGRP, GRP, SRIF, 5-HT, NSE, PHE, LK2H10, ER and Pgr were followed throughout the cultivation. An overexpression of the antiapoptotic gene bcl-2 was detected in the cell lines. Deregulation of apoptosis plays an important role in multistep tumorigenesis. MTCs are known for the phenomenon of bcl-2-based chemo- and radioresistance. Our studies focus on influencing the growth rates and modulating the apoptotic rates by treatment with proliferation-modifying substances and anticancer drugs. Our MTC cell lines are useful models for these in vitro studies.

Carcinoma, Medullary↗