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PubMed · 11064678

A paradoxical severe decrease in serum HDL-cholesterol after treatment with a fibrate.

M A Crook·J Lynas·R Wray
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Abstract

There have been a handful of reports in the literature of a paradoxical decrease in serum high density lipoprotein (HDL)-cholesterol in patients on fibrate drugs. The reason for this decline in cardioprotective HDL-cholesterol is not known and may have potential deleterious effects on the patient. This report describes a decrease in serum HDL-cholesterol in a patient on both simvastatin and bezafibrate. This patient also developed abnormal renal function, probably interstitial nephritis. In addition, the literature of fibrate induced serum HDL-cholesterol decline is reviewed and possible mechanisms for this phenomenon discussed.

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BezafibrateCholesterol, HDLHumansHypolipidemic AgentsMaleMiddle AgedNephritis, InterstitialCase ReportsJournal Article

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M A Crook, J Lynas, R Wray. 2000. A paradoxical severe decrease in serum HDL-cholesterol after treatment with a fibrate.. https://doi.org/10.1136/jcp.53.10.796

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Effects of bezafibrate and simvastatin on plasma lipoproteins in hypercholesterolemia resistant to hormone replacement therapy.

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PubMed2001

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