Methodologies for target selection in structural genomics.

M Linial; G Yona

doi:10.1016/s0079-6107(00)00011-0

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Methodologies for target selection in structural genomics.

M Linial·G Yona

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Abstract

As the number of complete genomes that have been sequenced keeps growing, unknown areas of the protein space are revealed and new horizons open up. Most of this information will be fully appreciated only when the structural information about the encoded proteins becomes available. The goal of structural genomics is to direct large-scale efforts of protein structure determination, so as to increase the impact of these efforts. This review focuses on current approaches in structural genomics aimed at selecting representative proteins as targets for structure determination. We will discuss the concept of representative structures/folds, the current methodologies for identifying those proteins, and computational techniques for identifying proteins which are expected to adopt new structural folds.

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Databases, Factual Genomics Protein Conformation Protein Folding Proteins Sequence Analysis, Protein Journal Article Research Support, Non-U.S. Gov't Review

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M Linial, G Yona. 2000. Methodologies for target selection in structural genomics.. https://doi.org/10.1016/s0079-6107(00)00011-0

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