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PubMed · 1101647

Synaptosomes containing large agranular vesicles isolated from developing rat brain.

L Kanerva·A Hervonen·A H Tissari
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Abstract

Using the subcellular fractionation technique the fine structure of the isolated nerve endings (synaptosomes) from the hemispheres and brain stem of the 1-day old and adult rat was examined. In the synaptosomal fractions of the brain of 1-day old rats we observed a new type of nerve endings containing predominantly large agranular vesicles about 1,000 A in diameter. After incubation with alpha-methylnoradrenaline or 5-hydroxydopamine these vesicles remained agranular. It is assumed that the new type of large vesicles represent developing synaptic vesicles.

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Age FactorsAnimalsAnimals, NewbornBrainBrain StemHydroxydopaminesNordefrinRatsSubcellular FractionsSynaptic VesiclesSynaptosomesJournal ArticleResearch Support, U.S. Gov't, Non-P.H.S.

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L Kanerva, A Hervonen, A H Tissari. 1975. Synaptosomes containing large agranular vesicles isolated from developing rat brain.. https://doi.org/10.1111/j.1748-1716.1975.tb05899.x

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