Search PubMed⌕ Search
Home/Archive/PubMed

PubMed · 11012391

Efavirenz-induced decrease in plasma amprenavir levels in human immunodeficiency virus-infected patients and correction by ritonavir.

X Duval·V Le Moing·C Longuet·C Leport·J L Vildé·C Lamotte·G Peytavin·R Farinotti
View original source ↗Export metadata ↓

Abstract

The source did not provide an abstract. Follow the original record for more information.

Explore related subjects

AlkynesAnti-HIV AgentsAryl Hydrocarbon HydroxylasesBenzoxazinesCarbamatesCyclopropanesCytochrome P-450 CYP3ACytochrome P-450 Enzyme InhibitorsDrug InteractionsDrug Therapy, CombinationFuransHIV InfectionsHumansOxazinesOxidoreductases, N-DemethylatingRitonavirSulfonamidesLetter

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

X Duval, V Le Moing, C Longuet, C Leport, J L Vildé, C Lamotte, G Peytavin, R Farinotti. 2000. Efavirenz-induced decrease in plasma amprenavir levels in human immunodeficiency virus-infected patients and correction by ritonavir.. https://doi.org/10.1128/aac.44.9.2593-2593.2000

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed2001

4,1-Benzoxazepinone analogues of efavirenz (Sustiva) as HIV-1 reverse transcriptase inhibitors.

A series of 4,1-benzoxazepinone analogues of efavirenz (Sustiva) as potent NNRTIs has been discovered. The cis-3-alkylbenzoxazepinones are more potent then the trans isomers and can be synthesized preferentially by a novel stereoselective cyclization. The best compounds are potent orally bioavailable inhibitors of both wild-type HIV-1 and its clinically relevant K103N mutant virus, but are highly protein-bound in human plasma.

Alkynes↗
PubMed2001

Target-directed enediynes: designed estramycins.

The goal of selective targeting of enediyne cytotoxins has been investigated using estrogenic delivery vehicles. A series of estrogen-enediyne conjugates were assembled, and affinity for human estrogen receptor [hERalpha] was determined. The most promising candidate induced receptor degradation following Bergman cycloaromatization and caused inhibition of estrogen-induced transcription in T47-D human breast cancer cells.

Alkynes↗