Search PubMed⌕ Search

PubMed · 11008933

An optical method for three-dimensional dosimetry.

Abstract

Accurate determination of the spatial distribution of the absorbed dose of ionising radiation plays an important role in radiotherapy, industrial radiation processing and many other applications. Computer calculations have frequently been used to estimate three-dimensional (3D) dose distributions in complex geometries and it becomes important to validate these by accurate 3D measurements. For this purpose we have been investigating the use of gelatin gels loaded with a modified Fricke solution which are pale orange in appearance and which, upon irradiation, become increasingly purple when viewed in normal light. This ferrous sulphate xylenol orange in gelatin gel (FXG) system displays very good properties, such as sensitivity, linearity and dynamic range, that make it suitable for 3D dosimetry applications. A high-speed optical tomography readout technique has been developed enabling two-dimensional projections of optical absorption data to be recorded rapidly. From these data the 3D absorbed dose distribution can quickly be derived with minimal degradation due to ion diffusion.

Explore related subjects

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

M A Bero, W B Gilboy, P M Glover. 2000. An optical method for three-dimensional dosimetry.. https://doi.org/10.1088/0952-4746%2F20%2F3%2F303

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

Multicolor single-molecule spectroscopy with alternating laser excitation for the investigation of interactions and dynamics.

We have developed confocal multicolor single-molecule spectroscopy with optimized detection sensitivity on three spectrally distinct channels for the study of biomolecular interactions and FRET between more than two molecules. Using programmable acousto-optical devices as beamsplitter and excitation filter, we overcome some of the limitations of conventional multichroic beamsplitters and implement rapid alternation between three laser lines. This enables to visualize the synthesis of DNA three-way junctions on a single-molecule basis and to resolve seven stoichiometric subpopulations as well as to quantify FRET in the presence of competing energy transfer pathways. Furthermore, the ability to study correlated molecular movements by monitoring several distances within a biomolecular complex simultaneously is demonstrated.

Color↗

Color naming reflects optimal partitions of color space.

The nature of color categories in the world's languages is contested. One major view holds that color categories are organized around universal focal colors, whereas an opposing view holds instead that categories are defined at their boundaries by linguistic convention. Both of these standardly opposed views are challenged by existing data. Here, we argue for a third view based on a proposal by Jameson and D'Andrade [Jameson KA, D'Andrade RG (1997) in Color Categories in Thought and Language, eds Hardin CL, Maffi L (Cambridge Univ Press, Cambridge, U.K.), pp 295-319]: that color naming across languages reflects optimal or near-optimal divisions of an irregularly shaped perceptual color space. We formalize this idea, test it against color-naming data from a broad range of languages and show that it accounts for universal tendencies in color naming while also accommodating some observed cross-language variation.

Color↗