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PubMed · 10968890

Structure-function studies on beta 2-glycoprotein I.

P G de Groot G·B Bouma·B C Lutters·M J Simmelink·R H Derksen·P Gros
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Abstract

Human beta 2-glycoprotein I is a heavily glycosylated plasma protein which has been implicated in the binding of antiphospholipid antibodies to negatively charged phospholipids; a process considered as an important risk factor for the development of thrombosis. We have solved the crystal structure of beta 2-glycoprotein I. In this review we will discuss what the three-dimensional structure teaches us about the role of beta 2-glycoprotein I in the pathogenesis of the antiphospholipid syndrome.

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GlycoproteinsHumansHydrogen-Ion ConcentrationPhospholipidsProtein BindingStructure-Activity Relationshipbeta 2-Glycoprotein IJournal ArticleReview

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P G de Groot G, B Bouma, B C Lutters, M J Simmelink, R H Derksen, P Gros. 2000. Structure-function studies on beta 2-glycoprotein I.. https://doi.org/10.1006/jaut.2000.0394

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