PubMed · 10833822
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2000. Tests may replace Pap smears.. https://pubmed.ncbi.nlm.nih.gov/10833822/
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Regional variations in intrapartum myometrial contractility were assessed using ultrasound. In 10 women with normal labours, the myometrial thickness increased in all areas during contractions, whilst in 10 women with slowly progressing labour, the retro-placental myometrium thinned during contractions. Locally acting placental tocolytics may be a cause of dysfunctional labour.
This study was undertaken to investigate the value of HPV testing in women referred with two abnormal smears that were graded as mild dyskaryosis or less who attended for at least three follow-up visits. One hundred forty-nine women were included in the study and a total of 39 high-grade lesions including one cancer were detected. All of these were found to be associated with the persistent presence of one or more of 13 high-risk human papillomavirus types (HPV) as detected by a multiplex type specific PCR technique. Two high-grade lesions were initially missed by cytology. In contrast, no cytological or histological evidence of high-grade lesions was found during a follow-up period of up to 8 years in 62 women with no high-risk HPV infection or in 38 women with only transient high-risk HPV infection. The utility of high-risk HPV detection in the management of women presenting with mild cytological abnormalities is discussed.
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