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PubMed · 10823278

Fast decrease of bleeding time by tranexamic acid in uremia.

D Mezzano·B Muñoz·E Pais·P Downey·J Pereira
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Bleeding TimeCombined Modality TherapyDrug EvaluationHemostaticsHumansRenal DialysisTranexamic AcidUremiaLetter

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D Mezzano, B Muñoz, E Pais, P Downey, J Pereira. 2000. Fast decrease of bleeding time by tranexamic acid in uremia.. https://pubmed.ncbi.nlm.nih.gov/10823278/

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[New in vitro analysis tested: bleeding time is still the best method for evaluation of primary hemostasis].

The need is great for a simple, cheap and readily accessible method for the evaluation of primary hemostasis in work-ups at both out-patient clinics and units caring for surgical or intensive care patients. PFA-100 is a recently introduced instrument for in vitro testing of platelet function. We report experiences from Stockholm, Gothenburg and Malmo of PFA-100 measurements performed on samples from healthy controls and from patients with von Willebrand disease or platelet disorders. It is shown that the PFA-100 system has a high sensitivity for von Willebrands disease, while the sensitivity for hereditary platelet dysfunction is low. In its present design this new device could not replace the template bleeding time as a screening test for primary hemostasis.

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PubMed2001

The relationship between hematocrit and bleeding time in very low birth weight infants during the first week of life.

OBJECTIVES: The bleeding time is a measurement of platelet and capillary interaction following a small standardized cutaneous incision. In adults, anemia causes a prolongation of the bleeding time, and we hypothesized that the same would be true in very low birth weight (VLBW) infants during their first week of life. STUDY DESIGN: Template bleeding times, using the Surgicutt Newborn device, were performed on 20 VLBW weight infants 0.28 l/l had no significant reduction in bleeding time following transfusion. CONCLUSIONS: In VLBW infants, during their first week of life (the time when their risk of intraventricular hemorrhage is greatest), a low hematocrit is associated with a significant prolongation in the bleeding time.

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