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PubMed · 10690507

Targeted toxins.

A E Frankel·R J Kreitman·E A Sausville
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Abstract

Targeted toxins, consisting of tumor-selective ligands coupled to polypeptide toxins, represent a new class of cancer therapeutics that kills malignant cells by inactivating cytosolic protein synthesis and inducing apoptosis. A number of these molecules have been produced under good manufacturing practice conditions and given systemically to patients with a variety of neoplasms. The promising results to date and the remaining pharmacological hurdles are discussed.

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Antineoplastic AgentsCytotoxinsDrug DesignHumansImmunotoxinsNeoplasmsJournal ArticleReview

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BibTeXRIS

A E Frankel, R J Kreitman, E A Sausville. 2000. Targeted toxins.. https://pubmed.ncbi.nlm.nih.gov/10690507/

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