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PubMed · 10673003

Super-integrons.

D A Rowe-Magnus·A M Guérout·D Mazel
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Abstract

Integrons represent the primary mechanism for antibiotic resistance gene capture and dissemination among gram-negative bacteria. The recent finding of super-integron (SI) structures in the genomes of several bacterial species has expanded their role in genome evolution. The Vibrio cholerae superintegron is gathered in a single chromosomal super-structure harbouring hundreds of gene cassettes. The encoded functions, when identifiable, are linked to adaptations extending beyond antibiotic resistance and pathogenicity. Comparison of the cassette contents of super-integrons from remote Vibrio species suggests that most of their cassettes are species-specific. Many bacterial species belonging to several distinct genera of the gamma- and beta-proteobacteria undoubtedly carry or show strong evidence for the presence of chromosomal SIs. If each bacterial species harbouring a SI has its own cassette pool, the resource in terms of gene cassette availability may be immense.

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Base SequenceDrug Resistance, MicrobialEvolution, MolecularGenes, BacterialGenome, BacterialIntegrasesMolecular Sequence DataProteobacteriaRecombination, GeneticRepetitive Sequences, Nucleic AcidSequence AlignmentSpecies SpecificityVibrioJournal ArticleResearch Support, Non-U.S. Gov'tReview

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D A Rowe-Magnus, A M Guérout, D Mazel. Super-integrons.. https://doi.org/10.1016/s0923-2508(99)00127-8

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