PubMed · 1040110
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M V Ivanova. 1975. [Chronic tonsillitis].. https://pubmed.ncbi.nlm.nih.gov/1040110/
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The analysis of heart rate variability (HRV) provides information about autonomic cardiovascular control in healthy subjects. In the past 15 years, several articles have been published regarding HRV and chronic heart failure (CHF). The results of these papers substantially demonstrated that HRV is significantly different in CHF patients compared to controls. Moreover, some variables derived from HRV analysis showed significant independent prognostic capacity. In particular, the reduction of variance (expressed as SDNN) and low-frequency spectral component of HRV (ranging from 0.03 to 0.15 Hz) seem related to an increased mortality in CHF. Nevertheless, these variables are not yet considered in clinical practice. A better understanding of the physiopathological basis of the reported alterations of HRV in CHF patients is required in order to permit its use as a clinical tool for prognosis and tailored therapy in individual CHF patients.
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Quantitative determination of viral nucleic acid in peripheral blood appears to be important for nearly all viral infections with a chronic and reactivating course, as this provides relevant information on the clinical consequences, the level of infectivity and the response to antiviral treatment or other interventions. The practical application of this principle in clinical virology has benefited from the availability of new techniques, particularly those in which amplification of viral nucleic acid can be followed in real time. In addition, the potential value of quantitative virology was clearly demonstrated by the experience gained from viral load monitoring in HIV-infected patients. This approach will probably be widely applicable in clinical microbiology in general.