A substrate combinatorial array for caspases.

D Lee; J L Adams; M Brandt; W E DeWolf; P M Keller; M A Levy

doi:10.1016/s0960-894x(99)00260-7

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A substrate combinatorial array for caspases.

D Lee·J L Adams·M Brandt·W E DeWolf·P M Keller·M A Levy

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Abstract

An efficient strategy for the synthesis of a tetrapeptidyl substrate combinatorial array directed toward the caspases is described. Testing of this array with caspases 1 and 4 gave substrate hydrolytic profiles characteristic of each caspase, and permitted the identification of efficiently processed substrates. A comparison of this approach to that using a positional scanning library is presented.

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Caspase 1 Caspases Caspases, Initiator Catalysis Kinetics Oligopeptides Substrate Specificity Journal Article

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D Lee, J L Adams, M Brandt, W E DeWolf, P M Keller, M A Levy. 1999-06-21. A substrate combinatorial array for caspases.. https://doi.org/10.1016/s0960-894x(99)00260-7

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