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Increased uncoupling protein2 mRNA in white adipose tissue, and decrease in leptin, visceral fat, blood glucose, and cholesterol in KK-Ay mice fed with eicosapentaenoic and docosahexaenoic acids in addition to linolenic acid.

C S Hun·K Hasegawa·T Kawabata·M Kato·T Shimokawa·Y Kagawa
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Abstract

The effects of n-3 polyunsaturated fatty acids (n-3PUFA) on obesity and diabetes were examined using KK-Ay mice fed with perilla oil (P), soybean oil (S), or lard (L), and those containing 30% fish oil (PF, SF, or LF), containing eicosapentaenoic acid (EPA = 9.9%) and docosahexaenoic acid (DHA = 18.0%). Perilla oil contained the largest proportion of linolenic acid (LNA = 61.9%). Computerized tomography (CT) scans showed narrower areas of visceral fat in the abdominal cross sections of groups given fish oil (PF, SF, and LF) and lower leptin levels (p < 0.05-p < 0.001) compared with controls (P, S, and L), without significant changes in energy intake and body weight. The highest plasma n-3PUFA content (21.31 +/- 0.35%) was attained with PF. This group contained 2.6-fold more plasma DHA (p < 0.001), and expressed 2.7-fold more UCP2 mRNA in white adipose tissue (p < 0.01) than in the P group. The epididymal fat pad (p < 0.05) weighed less, and levels of blood glucose (p < 0.05) and total cholesterol (p < 0.01) were reduced in PF compared with P.

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Adipose TissueAnimalsBlood GlucoseBody WeightCholesterolDiabetes MellitusDietDocosahexaenoic AcidsEicosapentaenoic AcidFatty Acids, Omega-3Ion ChannelsLeptinMaleMembrane Transport ProteinsMiceMice, Inbred StrainsMitochondrial ProteinsObesityOrgan SizeProteinsRNA, MessengerTomography, X-Ray ComputedUncoupling Protein 2alpha-Linolenic AcidJournal Article

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C S Hun, K Hasegawa, T Kawabata, M Kato, T Shimokawa, Y Kagawa. 1999-05-27. Increased uncoupling protein2 mRNA in white adipose tissue, and decrease in leptin, visceral fat, blood glucose, and cholesterol in KK-Ay mice fed with eicosapentaenoic and docosahexaenoic acids in addition to linolenic acid.. https://doi.org/10.1006/bbrc.1999.0733

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