Dynamin spirals.

J E Hinshaw

doi:10.1016/s0959-440x(99)80036-0

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PubMed · 10322220

Dynamin spirals.

J E Hinshaw

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Abstract

Dynamin is an important component of membrane recycling at the plasma membrane and, potentially, within the cell. The role of dynamin in clathrin-mediated endocytosis has been based on numerous endocytosis assays, as well as on the discovery and gross characterization of the assembled spiral structure of dynamin. Recently, it has been shown that dynamin can also bind to liposomes and form helical tubes that constrict and vesiculate upon GTP addition. This suggests that dynamin is capable of and may be responsible for the pinching off of clathrin-coated vesicles from the plasma membrane during clathrin-mediated endocytosis.

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Amino Acid Sequence Animals Binding Sites Dynamins Endocytosis GTP Phosphohydrolases Guanosine Triphosphate Hydrolysis Macromolecular Substances Microscopy, Electron Journal Article Review

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J E Hinshaw. 1999. Dynamin spirals.. https://doi.org/10.1016/s0959-440x(99)80036-0

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