PubMed · 10287701
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1988. Methods for limiting EO exposure.. https://pubmed.ncbi.nlm.nih.gov/10287701/
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A convenient method for the oxidation of nucleoside phosphites into phosphates under nonbasic and nonaqueous conditions using commercially available ethyl(methyl)dioxirane has been developed. This oxidation is effective with both N-protected and N-unprotected strategies.
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The author analysed hazardous effects of exposure to ethylene oxide among hospital personnel involved in sterilization of medical instruments and equipment. Toxicity of ethylene oxide was discussed, including its sensitizing, neurotoxic, mutagenic and carcinogenic effects as well as its influence on procreation. Hazardous effect of high, transient concentrations of ethylene oxide occurring in certain sterilization processes was highlighted. Preventive methods for reducing exposure to ethylene oxide hospitals were proposed.