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PubMed · 102478

Complement activity in middle ear effusions.

J M Bernstein·H A Schenkein·R J Genco·W R Bartholomew
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Abstract

Evidence for complement utilization in middle ear fluids (MEF) from patients with otitis media with effusion was sought. It was found that cleavage products of C3, C4 and Factor B could be demonstrated immunochemically in MEF, and that native C3 was present in much lower concentrations than other proteins, relative to their serum concentrations. Haemolytic assays for C1-C5 showed that early complement components are inactivated in MEF. Potential mechanisms for complement utilization in MEF are discussed.

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ChildComplement C3Complement C4Complement Factor BComplement System ProteinsEar, MiddleExudates and TransudatesHumansImmunodiffusionImmunoelectrophoresisImmunoglobulin AImmunoglobulin GOtitis MediaJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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J M Bernstein, H A Schenkein, R J Genco, W R Bartholomew. 1978. Complement activity in middle ear effusions.. https://pubmed.ncbi.nlm.nih.gov/102478/

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