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PubMed · 10224665

LIM-kinase1.

C A Stanyon·O Bernard
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Abstract

LIM-kinase1 (LIMK1) is a serine-only protein kinase that contains LIM and PDZ protein-protein interaction domains which is highly expressed in neurons. Overexpression of LIMK1 in cultured cells results in accumulation of filamentous (F-) actin. LIMK1 phosphorylates cofilin, an actin depolymerisation factor, which is then unable to bind and depolymerise F-actin. Rac-GTP enhances phosphorylation of LIMK1 and cofilin, which leads to accumulation of F-actin, while Rac-GDP and PMA reduce these effects. LIMK1 is therefore a key component of a signal transduction network that connects extracellular stimuli to changes in cytoskeletal structure. Control of cell morphology and mobility via LIMK1 activity may provide novel approaches to cancer therapy.

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HumansLim KinasesModels, BiologicalProtein KinasesTissue DistributionWilliams SyndromeJournal ArticleReview

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C A Stanyon, O Bernard. LIM-kinase1.. https://doi.org/10.1016/s1357-2725(98)00116-2

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