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PubMed · 10220871

Equilin.

M W Sawicki·N Li·D Ghosh
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Abstract

3-Hydroxyestra-1,3,5(10),7-tetraen-17-one, C18H20O2, crystallizes in space group P2(1)2(1)2(1) from ethyl acetate. The planarity of the B ring, and the difference in puckering of the C and D rings from that of estrone, are due to the presence of the C7 = C8 double bond, which may explain its function as an inhibitor of human type 1 17 beta-hydroxysteroid dehydrogenase, instead of being its substrate.

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Crystallography, X-RayEquilinEstrogen Replacement TherapyHumansModels, MolecularJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.

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M W Sawicki, N Li, D Ghosh. 1999-03-15. Equilin.. https://doi.org/10.1107/s0108270198013250

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