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PubMed · 10216941

Translation initiation factor 4E.

L McKendrick·V M Pain·S J Morley
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Abstract

Translation initiation factor 4E (eIF4E) binds the 7-methylguanosine cap structure of mRNA and mediates recruitment of mRNA to ribosomes, with the potential of regulating the overall rate of translation and discriminating between different RNAs. Increased translation is required for progress through the cell cycle, and it is therefore not surprising that eIF4E has oncogenic properties when overexpressed. The function of this review is to summarise what is known about eIF4E gene and protein structure, biological function and medical relevance.

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Amino Acid SequenceAnimalsCell Transformation, NeoplasticEukaryotic Initiation Factor-4EHumansMolecular Sequence DataPeptide Initiation FactorsPhosphorylationRNA, RibosomalSequence Homology, Amino AcidJournal ArticleResearch Support, Non-U.S. Gov'tReview

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L McKendrick, V M Pain, S J Morley. 1999. Translation initiation factor 4E.. https://doi.org/10.1016/s1357-2725(98)00129-0

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