Search PubMed⌕ Search

PubMed · 10171174

Angioscopy.

Abstract

Over the last year, research using flexible, ultrathin fiberoptics for vascular imaging (angioscopy) has continued to demonstrate its clinical potential. Vascular surgeons, thus far angioscopy's strongest advocates, have repeatedly demonstrated that the use of this procedure during peripheral vascular bypass surgery can improve graft patency rates. Although it is doubtful that angioscopy could ever replace angiography, the qualitative details of a vessel's surface disclosed by angioscopy are significant and not available by other means, including intravascular ultrasound. Investigators have used angioscopy to evaluate the burgeoning number of new, catheter-based vascular technologies. A combination of angioscopy and laser or atherectomy, however appealing, will require major technologic advances. One such advance has been the balloon-tipped catheter for blood-free imaging, which circumvents the need for potentially hazardous saline flush. Such an imaging system has provided new insights into the diseased myocardium of living patients.

Explore related subjects

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

C T Sherman. 1991. Angioscopy.. https://doi.org/10.1097/00001573-199108000-00007

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

Calcium signaling and oxidant stress in the vasculature.

Recent evidence suggests that oxidant stress plays a major role in several aspects of vascular biology. Oxygen free radicals are implicated as important factors in signaling mechanisms leading to vascular pathologies such as postischemic reperfusion injury and atherosclerosis. The role of intracellular Ca(2+) in these signaling events is an emerging area of vascular research that is providing insights into the mechanisms mediating these complex physiological processes. This review explores sources of free radicals in the vasculature, as well as effects of free radicals on Ca(2+) signaling in vascular endothelial and smooth muscle cells. In the endothelium, superoxides enhance and peroxides attenuate agonist-stimulated Ca(2+) responses, suggesting differential signaling mechanisms depending on radical species. In smooth muscle cells, both superoxides and peroxides disrupt the sarcoplasmic reticulum Ca(2+)-ATPase, leading to both short- and long-term effects on smooth muscle Ca(2+) handling. Because vascular Ca(2+) signaling is altered by oxidant stress in ischemia-related disease states, understanding these pathways may lead to new strategies for preventing or treating arterial disease.

Blood Vessels↗

Hue-saturation-density (HSD) model for stain recognition in digital images from transmitted light microscopy.

BACKGROUND: Transmitted light microscopy is used in pathology to examine stained tissues. Digital image analysis is gaining importance as a means to quantify alterations in tissues. A prerequisite for accurate and reproducible quantification is the possibility to recognise stains in a standardised manner, independently of variations in the staining density. METHODS: The usefulness of three colour models was studied using data from computer simulations and experimental data from an immuno-doublestained tissue section. Direct use of the three intensities obtained by a colour camera results in the red-green-blue (RGB) model. By decoupling the intensity from the RGB data, the hue-saturation-intensity (HSI) model is obtained. However, the major part of the variation in perceived intensities in transmitted light microscopy is caused by variations in staining density. Therefore, the hue-saturation-density (HSD) transform was defined as the RGB to HSI transform, applied to optical density values rather than intensities for the individual RGB channels. RESULTS: In the RGB model, the mixture of chromatic and intensity information hampers standardisation of stain recognition. In the HSI model, mixtures of stains that could be distinguished from other stains in the RGB model could not be separated. The HSD model enabled all possible distinctions in a two-dimensional, standardised data space. CONCLUSIONS: In the RGB model, standardised recognition is only possible by using complex and time-consuming algorithms. The HSI model is not suitable for stain recognition in transmitted light microscopy. The newly derived HSD model was found superior to the existing models for this purpose.

Blood Vessels↗