Search PubMed⌕ Search

PubMed · 10149572

Antiarrhythmic surgery.

Abstract

Medically refractory tachyarrhythmias remain a significant clinical problem. The indications for surgical intervention in this challenging patient population continue to expand. Advances in noninvasive detection of patients at risk, as well as expanding electrophysiologic testing, continue to help define patients best served by surgical therapy. Refinements in surgical techniques, including rapid computerized intraoperative arrhythmia mapping, have made operative therapy safer and more effective. This review describes recent observations and advances in surgical therapy for supraventricular and ventricular tachyarrhythmias.

Explore related subjects

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

M A Grosso, A H Harken. 1991. Antiarrhythmic surgery.. https://doi.org/10.1097/00001573-199102000-00010

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

Acute effects of estrogen on neuronal physiology.

It has been known for more than 30 years that estrogen can alter the intrinsic and synaptic physiology of neurons within minutes. The physiological significance of these acute effects has been unclear, however, because some effects require higher concentrations of estrogen than are detected in plasma, and because estrogen secreted by the ovary rises and falls over a time course of days, not minutes. These concerns may be answered by new research demonstrating that estrogen is produced at high levels within the brain itself, and that production of estrogen in the brain may be regulated by neuronal activity. Additionally, recent studies indicate that classical estrogen receptor proteins are found not only in the nucleus where they regulate gene expression but also at extranuclear sites, including at synapses. These findings, together with evidence for new types of extranuclear estrogen receptors, suggest that estrogen might act directly at synapses to activate second messenger signaling, thereby rapidly altering neuronal excitability, synaptic transmission, and/or synaptic plasticity.

Electrophysiology↗