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PubMed · 10147431

Current transfusion therapy: indications for basic components.

E F Williams
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Abstract

OBJECTIVE: To review basic blood components and currently acceptable transfusion practices. DATA SOURCES: Professional journals, current texts, and the author's experience. STUDY SELECTION: Not applicable. DATA EXTRACTION: Not applicable. DATA SYNTHESIS: Red blood cells, platelets, cryoprecipitate, and fresh-frozen plasma are the basic blood components ordered daily in hospitals and transfusion services all over the world. To notify the laboratory medical director of inappropriate orders for components, the clinical laboratory scientist must be aware of currently acceptable transfusion practices. This article reviews these four components and indicates acceptable processing methods and appropriate use. CONCLUSION: Considering the known risk factors of blood and blood component transfusions, it is essential that components be used only when necessary. Criteria for appropriate transfusion have changed over the years; old transfusion triggers are no longer acceptable. To provide the best medical care to the patient, the clinical laboratory scientist must stay abreast of currently acceptable transfusion practices.

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Blood Component TransfusionBlood PlateletsHumansPlasmaPractice Guidelines as TopicJournal ArticleReview

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E F Williams. Current transfusion therapy: indications for basic components.. https://pubmed.ncbi.nlm.nih.gov/10147431/

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PubMed1999

Serious hazards of transfusion (SHOT) initiative: analysis of the first two annual reports.

OBJECTIVE: To receive and collate reports of death or major complications of transfusion of blood or components. DESIGN: Haematologists were invited confidentially to report deaths and major complications after blood transfusion during October 1996 to September 1998. SETTING: Hospitals in United Kingdom and Ireland. SUBJECTS: Patients who died or experienced serious complications, as defined below, associated with transfusion of red cells, platelets, fresh frozen plasma, or cryoprecipitate. MAIN OUTCOME MEASURES: Death, "wrong" blood transfused to patient, acute and delayed transfusion reactions, transfusion related acute lung injury, transfusion associated graft versus host disease, post-transfusion purpura, and infection transmitted by transfusion. Circumstances relating to these cases and relative frequency of complications. RESULTS: Over 24 months, 366 cases were reported, of which 191 (52%) were "wrong blood to patient" episodes. Analysis of these revealed multiple errors of identification, often beginning when blood was collected from the blood bank. There were 22 deaths from all causes, including three from ABO incompatibility. There were 12 infections: four bacterial (one fatal), seven viral, and one fatal case of malaria. During the second 12 months, 164/424 hospitals (39%) submitted a "nil to report" return. CONCLUSIONS: Transfusion is now extremely safe, but vigilance is needed to ensure correct identification of blood and patient. Staff education should include awareness of ABO incompatibility and bacterial contamination as causes of life threatening reactions to blood.

Blood Component Transfusion↗