Biomedical subjects

Zofia Ostrowska

Publications and source records attributed to Zofia Ostrowska.

20 records · Page 2Linked to original sources

PubMedDate not supplied

[The effect of a single electroconvulsive shock on pituitary-thyroid-adrenal-gonadal axis function in men with severe depression--preliminary report].

INTRODUCTION AND AIM: Electroconvulsive therapy (ECT) is an effective treatment of severe depression but its mechanism of action is still unknown. The aim of the study was to investigate the effect of first ECT on serum hormone concentrations in patients with severe depression. MATERIAL AND METHOD: Serum concentrations of prolactin (PRL), adrenocorticotropin (ACTH), thyrotrophin (TSH), luteinizing hormone (LH), follicle stimulating hormone (FSH), cortisol (F), triiodothyronine (T3), thyroxine (T4), estradiol (E2), progesterone (P) and testosterone (T) were estimated by RIA or IRMA in 5 men (mean age 34.20 +/- 8.70 years) with severe depression. Before ECT, all men were receiving psychotropic medication. None of the patients had clinical symptoms of endocrine disorders. Blood samples for hormonal investigations were taken before and 15 min., 2 hours, 6 h, 12 h, 24 h after the first electroconvulsive shock. The men without endocrine dysfunction in the same range of age who underwent identical intravenous anaesthesia for minor maxillofacial surgery were studied as controls. RESULTS: Before and after first ECT mean serum LH, T and T3 concentrations were significantly decreased and PRL, F and E mean levels were significantly elevated in men with depression as compared with the control group. No significant changes in mean serum hormone concentrations after ECT as compared to levels before ECT were observed. CONCLUSION: (1) Single electroconvulsive shock insignificantly changes the pituitary-thyroid-adrenal-gonadal axis function. (2) Complicated hormonal changes found before electroconvulsive shock in patients with severe depression suggest the influence of psychotropic treatment as well as the illness on the endocrine system.

Adrenal Cortex Hormones↗

PubMedDate not supplied

[Influence of pinealectomy and long-term melatonin administration on bone metabolism in orchidectomized rats].

INTRODUCTION: The aim of the study was to demonstrate whether pinealectomy and long-term MEL administration can affect bone metabolism (as evaluated on the basis of serum concentrations of PICP and ICTP) in orchidectomized rats. MATERIAL AND METHODS: The study included 248 adult male Wistar rats; 6 remained intact, 120 were orchidectomized (Orch), and the remaining ones underwent a sham operation (SOrch). Two weeks after surgery, the rats were divided into 8 groups: 1) SOrch + SPx; 2) SOrch + SPx + MEL; 3) Orch + SPx; 4) Orch + SPx + MEL; 5) SOrch + Px; 6) SOrch + Px + MEL; 7) Orch + Px; 8) Orch + Px + MEL. Animals from 5(th), 6(th), 7(th) and 8(th) groups were pinealectomized (Px) while the remaining ones underwent a sham operation (SPx). Two weeks after surgery rats in the 2(nd), 4(th), 6(th) and 8(th) groups were administered MEL (50 microg/100 g of bm) intraperitoneally while the remaining animals were administered solvent only (daily between 5 and 6 pm during a month). The animals were decapitated before the experiment (intact rats), after 2 weeks from Orch and SOrch, Px and SPx, after 4 weeks from MEL or solvent administration and after 4 and 8 weeks from discontinuing administration of MEL, and blood was collected for PICP and ICTP concentrations assays with the use of RIA method. DISCUSSION: In Orch rats, a distinct tendency to increase the studied bone markers, especially ICTP was shown. Pinealectomy had inducing, while MEL suppressing effect upon the level of PICP and ICTP; these changes were more pronounced in Orch + Px and SOrch + Px + MEL groups, respectively. After discontinuing administration of MEL distinct tendency to increase of PICP and ICTP level was shown. CONCLUSIONS: Our findings indicate that MEL is an important modulator of bone tissue metabolism in male rats and that deficiency of MEL concentration may be a co-factor in osteoporosis development.

Animals↗