Biomedical subjects

Zhizhong Shen

Publications and source records attributed to Zhizhong Shen.

8 recordsLinked to original sources

PubMed2005

[Tinnitus with normal hearing and evoked otoacoustic emissions].

OBJECTIVE: To investigate the objective methods for tinnitus exploration by analysing the cochlear activity in tinnitus patients with normal hearing. METHOD: The 50 cases (50 ears) of unilateral tinnitus with normal hearing (the plastic group 1), 24 cases (46 ears) of bilateral tinnitus with normal hearing(the plastic group 2) and the 34 persons (68 ears) of normal hearing without tinnitus (control group) were measured by evoked otoacoustic emissions (TEOAE and DPOAE). All the tinnitus patients were also tested by the subjective tinnitus frequency and analysed with appropriate characteristic in TEOAE and DPOAE audiogram. RESULT: (1) The passing rate of TEOAE was 64.0% in the tinnitus group 1, 91.3% in the group 2, and 100% in the control group (group 1 P < 0.01, group 2 P >0.05 ). (2) The passing rate of DPOAE was 100% in three groups. But comparing to the control group, the amplitudes of DPOAE at the limited frequency ranges (3.125 kHz and 8.837 kHz) of the tinnitus group 1 was significant decreased ( P <0.05). (3) The subjective tinnitus frequencies were 0.25 approximately 8.00 kHz. The decreases in amplitudes and absent within the tinnitus frequencies were observed in TEOAE and DPOAE audiogram. CONCLUSION: Some patients of normal hearing with tinnitus have had early harmness of outer hair cell in cochlear. Evoked otoacoustic emissions is one of worthy methods to evaluated objectively the tinnitus. TEOAE is more susceptible to harmness in cochlear than DPOAE. DPOAE is superior to the analysis of tinnitus frequencies.

Adolescent↗

PubMed2005

[Extraluminal foreign body originated from pharynx and esophagus (24 cases report)].

OBJECTIVE: To summarize the symptoms, various diagnostic procedures, and therapy of extraluminal foreign body originated from pharynx and esophagus (EFBOPE). METHOD: Twenty-four patients with EFBOPE were retrospectively reviewed. RESULT: Twenty-two cases were removed surgically, 1 case was spontaneous expulsion, 1 case died. CONCLUSION: EFBOPE is seldom seen in the clinical, diagnosis of EFBOPE should be considered whenever haematemesis or haemorrhage, inflammation or abscess in parapharyngeal space outside of pharynx and esophagus are presented after ingesting foreign body. Radiography and computed tomography are main diagnostic tools. Surgical treatment is the only effective method for EFBOPE and must be performed in time.

Adolescent↗

PubMed2005

[The diagnosis and surgical treatment for bleeding polyp in paranasal sinus and nasal cavity (with 23 cases reported)].

OBJECTIVE: To study the diagnosis and the therapy for bleeding polyp in paranasal sinus and nasal cavity(BPPSNC), and to improve its diagnosis and treatment level. METHOD: A retrospective analysis was performed on 23 cases with BPPSNC by the diagnosis and the therapy. RESULT: Before operation, three cases were considered as malignant tumor, and five cases could not be diagnosed definitely. Cald well-Luc operation was performed on 20 cases, only one case was performed by lateral rhinotomy and two cases were performed by nasal approach. Following up for 0. 8 to 10 years, all cases were cured. CONCLUSION: The primary definite diagnosis is difficult before operation. Puncture and irrigation of the maxillary sinus is very valuable for the diagnosis of BPPSNC. It is important for CT scanning to diagnose and design the operative method of BPPSNC. It is a good surgical approach that Cald well-Luc operation is performed for BPPSNC.

Adult↗

PubMed2005

[Comprehensive evaluation of the middle ear function in children with secretory otitis media after tympanotomy tube insertion].

OBJECTIVE: To study the method on comprehensive evaluation of the middle ear function in children with secretory otitis media (SOM) after tympanotomy tube insertion. METHOD: Ear canal volume (ECV), pure tone audiometry and distortion product otoacoustic emission(DPOAE) were carried out in 31 children(43 ears) with SOM before and 1 month after tube insertion,in the meantime Eustachian tube function was recorded. The tympanotomy tube was observed under microscope. RESULT: After one month of tube insertion, the hearing level was improved in 39 ears with an ECV > 2.0 ml. In addition,the detection rate and amplitude of DPOAE were significantly increased in these 39 ears. No case of the function of Eustachian tube was complete recovered. CONCLUSION: ECV, pure tone audiometry, DPOAE and inflation-deflation test are significantly clinical worth for comprehensive evaluation of the middle ear function in children with SOM after tympanotomy tube insertion.

Acoustic Impedance Tests↗

PubMed2004

[Security assortment and guarding method after tracheotomy].

OBJECTIVE: To discuss the assortment method of security and to find out measures in order to avoid the asphyxia death owing to obstruction and collapse of canal after tracheotomy. METHOD: During the period from June 1998 to September 2003, 346 patients were operated the tracheotomy for different reasons. Then they were assorted according to the causes if there was an obstruction in superior airway, the patients' mental health, age and the capacity of saving themselves. We divided them into three kinds, which were security, dangerousness (temporalily or permanently) and relative dangerousness. The corresponding methods of operation therapy and nursing care had been proposed. RESULT: One hundred and sixty cases were the secure kind; 17 cases the dangerous kind (12 cases permanently, 5 cases temporalily), 169 cases the relatively dangerous kind. After adopting corresponding method of operation and nursing cars, the asphyxia death due to obstruction or collapse of canal didnt happen. CONCLUSION: The security assortment has significance after tracheotomy for reducing the asphyxia death rate.

Adolescent↗

PubMed2003

[Surgical treatment for the chronic severe aspiration].

OBJECTIVE: To find out the best surgical treatment for chronic severe aspiration with different pathogenesis. METHOD: Eight patients with severe aspiration were treated by 3 surgical methods. Six of 8 cases were perfomed tracheotomy. The cannula had a gasbag and the gasbag was inflated before eating food every time. Epiglottic flap closure for one patient with intractable aspiration. Stomach-stomy for the case with tracheoasophageal fistula. RESULT: There did not found aspiratory pneumonia in all cases after following up for 9 months to 4.5 years. The six cases with tracheotomy could eating normally and their phonation were reserved. Only one case has a slight aspiration. The patient with epiglottic flap closure hadn't aspirated when eating. The stomach-stomy could prevent the aspiration in having meal. CONCLUSION: Tracheotomy, epiglottic flap closure and stomach-stomy are all the effective surgical treatment for chronic severe aspiration. Any of 3 surgical methods should be selected according to the etiology, the degree of aspiration and the patient's condition, so as to improve the quality of the patient's life.

Adult↗

PubMed2002

[The effects of BDP on calcium ion in the granular leukocytes in nasal secretions of the patients with allergic rhinitis].

OBJECTIVE: To study the effects of beclomethasone dipropionate (BDP) on the inflammatory granular leukocytes in nasal secretions of the patients with allergic rhinitis. METHOD: The change of intercellular calcium ion of the eosinophils and neutrophils in the nasal secretions were observed under the laser scanning confocal microscopy and technology of fluorescence. RESULT: The concentration of intercellular calcium ion either in eosinophils or in neutrophils significantly rose after BDP treatment. CONCLUSION: BDP can rise the concentration of intercellular calcium ion in the granular leukocytes, which may be a factor of the anti-inflammation functions of BDP.

Anti-Inflammatory Agents↗

PubMed2002

[Study on the expression of connexin 43 in human nasopharyngeal carcinoma].

OBJECTIVE: To study the relationship of the expression of connexin 43 (Cx43) in human nasopharyngeal carcinoma (NPC). METHOD: The cell shape and the expression of Cx43 in 18 cases of NPC and 10 cases of chronic inflammation disease of nasopharyngeal epitheliems (CIDNE) were observed under the laser scanning confocal microscopy and technology of fluorescence. RESULT: The scanning images displayed that the fluorescence signal of Cx43 in cell membrane of NPC was significantly lower than in CIDNE (P < 0.01). CONCLUSION: The expression of Cx43 plays an important role in the development of NPC. The reduced or loss of gap junctional intercellular communication may be one of the important factors in the development of a normal nasopharyngeal epithelium cell into a neoplastic one.

Aged↗