Biomedical subjects

Zhen Ye

Publications and source records attributed to Zhen Ye.

21 records · Page 2Linked to original sources

PubMed2002

Propagation inhibition and wave localization in a two-dimensional random liquid medium.

Acoustic propagation and scattering in water containing many parallel air-filled cylinders is studied in an exact manner. Two situations are considered and compared; (1) wave propagating through the array of cylinders, imitating common experimental setups, and (2) wave transmitted from a source located inside the ensemble. We show that waves can be blocked from propagation by disorders in the first scenario, but such an inhibition does not necessarily lead to actual wave localization in the medium. The results indicate that the traditional method may be ambiguous in discerning localization effects. Furthermore, the results reveal the phenomenon of wave localization in a range of frequencies.

Journal Article↗

PubMed2002

Profiling alternative splicing on fiber-optic arrays.

The human transcriptome is marked by extensive alternative mRNA splicing and the expression of many closely related genes, which may be difficult to distinguish using standard microarray techniques. Here we describe a sensitive and specific assay for parallel analysis of mRNA isoforms on a fiber-optic microarray platform. The method permits analysis of mRNA transcripts without prior RNA purification or cDNA synthesis. Using an endogenously expressed viral transcript as a model, we demonstrated that the assay readily detects mRNA isoforms from as little as 10-100 pg of total cellular RNA or directly from a few cells. Multiplexed analysis of human cancer cell lines revealed differences in mRNA splicing and suggested a potential autocrine mechanism in the development of choriocarcinomas. Our approach may be useful in the large-scale analysis of the role of alternative splicing in development and disease.

Alternative Splicing↗

PubMed2002

Intraoperative ultrasonography in hepatobiliary surgery.

OBJECTIVE: To assess the value of intraoperative ultrasonography in hepatobiliary surgery. METHODS: Aloka-650 and Aloka-500 with a 3.5 MHz probe were used in preoperative ultrasonography and those with 5 MHz or 7.5 MHz probes in intraoperative ultrasonography. All patients with carcinoma were confirmed pathologically. RESULTS: In 44 patients with liver cancer (76 tumors), the diagnostic rate of intraoperative ultrasonography was 97% (74/76), which was markedly higher than 84% (64/76) of preoperative ultrasonography (P<0.05). The diagnostic rate (92%; 22/24) of intraoperative ultrasonography for tumors </=2 cm in diameter was markedly higher than that (54%; 13/24) of preoperative ultrasonography (P<0.01). The diagnostic rate (94%; 16/17) of intra-operative ultrasonography for tumor embulus of the vein was also markedly higher than that (53%; 9/17) of preoperative ultrasonography (P<0.01). The diagnostic rates of intraoperative and preoperative ultrasonography for cholelithiasis were 99% (108/109) and 97% (106/109) respectively (P>0.05). Yet the diagnostic rate (100%; 12/12) of intraoperative ultrasonography for gallbladder carcinoma was markedly higher than that (66.7%; 8/12) of pre-operative ultrasonography (P<0.05). The diagnostic rates of intraoperative ultrasonography for choledocholith and biliary tract cancer were all 100%, markedly higher than those (83%; 20/24 and 75%; 12/16) of preoperative ultrasonography (P<0.05). CONCLUSIONS: Intraoperative ultrasonography can raise the detective rate of the liver occupying lesions comparing with that of preoperative untrasonography. It is of valuable in selecting operative scheme and locating small lesions.

Adult↗